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Pinealon

Also known as EDR peptide, Glu-Asp-Arg

Animal studies only

Synthetic tripeptide from the same research group as epitalon. Published research is limited to cell and animal studies.

Not an approved medicine. Pinealon is not an approved medicine for this use in Australia or the United States. This page summarises published research for information only. It is not a recommendation to use Pinealon, and VialOwl does not sell or supply it.

Background

Pinealon is a synthetic three amino acid peptide (glutamic acid, aspartic acid, arginine; EDR). It comes from the St Petersburg group led by Vladimir Khavinson that also developed epitalon, as part of their 'peptide bioregulator' research.

How it is thought to work

Cell studies suggest it lowers reactive oxygen species and cell death under oxidative stress. The developers propose that it enters cells and directly influences gene activity, but this has not been independently confirmed.

What is claimed, and the evidence

ClaimEvidenceNotes
Protects brain cells from oxidative stressAnimal studies onlyCell culture and rat studies from the developing group.
Improves memory in elderly peopleNo published evidenceStated in a review by the group that developed it, but the underlying human study could not be found, so this is treated as unsupported.
Anti ageing, sleep and cognitive enhancementNo published evidenceMarketed claims; no independent human trials.

Side effects

EffectHow oftenNotes
Any human side effectsFrequency unknownNo published human safety data were found.
Immune reactions or contamination
Serious		Frequency unknownGeneral risk for unapproved peptide products.

Warnings

  • Research comes almost entirely from one group and has not been independently replicated.
  • Unapproved products are not assessed by the TGA for quality, safety or efficacy and may be contaminated, non-sterile, underdosed, overdosed or contain a different substance altogether.

Regulatory status

Australia
Not included on the ARTG (unapproved). Not specifically listed in the Poisons Standard (June 2026).
United States
Not FDA approved. No FDA compounding category entry found.

Sources

  1. PubMed: Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes
  2. PubMed: Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
  3. PubMed: EDR Peptide: possible mechanism of gene expression and protein synthesis regulation in Alzheimer's disease

Also in Longevity

From the VialOwl library, reviewed 26 September 2026. For education and general information. It is not medical advice and not a recommendation to use Pinealon.